FIELD: medicine; pharmacology.
SUBSTANCE: pharmaceutical composition intended for treatment of solid tumours, contains 5, 10-methylene-(6R)-, -(6S)- or -(6R, S)-tetrahydrofolate together with citrate and has pH in a range from 7.5 to 10.5, preferable from 8.5 to 9.5. The solutions of 5,10-methylentetrahydrofolic acids and lyophilizates, prepared according to the present invention, are stable during the long period of time even without addition of reducers (antioxidants) and without an exception of atmospheric oxygen.
EFFECT: lyophilizates can be easily restored by addition of water or aqueous solutions and final transparent solutions for injections also possess good characteristics of stability.
15 cl, 8 ex
| Title |
Year |
Author |
Number |
| STABLE LYOPHILIZATES CONTAINING 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID |
2018 |
- Moser Rudolf
- Groehn Viola
- Ammann Thomas
|
RU2796570C2 |
| STABLE AQUEOUS COMPOSITIONS OF CYCLODEXTRIN INCLUSION COMPOUNDS, COMPOUNDS INCLUDING α-,β- or γ- DEXTRIN OR ITS ALKYL- OR HYDROXYALKYL DERIVATIVES AND (6R)-OR (6S)-5,10- METHYLENE TETRAHYDROFOLIC ACID OR ITS SALT, METHOD OF STABILIZING AQUEOUS SOLUTIONS, AND METHOD OR PREPARING STABLE SOLUTIONS |
1993 |
- Khans Rudol'F Mjuller
- Martin Ul'Mann
- Jozef Konti
|
RU2135519C1 |
| METHOD OF SYNTHESIS OF (6S)- OR (6R)-TETRAHYDROFOLIC ACID |
1991 |
- Dr.Gans Rudol'F Mjuller[Ch]
- Martin Ulmann[Ch]
- Esef Konti[Ch]
- Gjunter Mjurdel[De]
|
RU2099340C1 |
| METHODS FOR INCREASING LEVEL OF 2'-DEOXYURIDINE (DURD) IN PLASMA AND INHIBITING THYMIDYLATE SYNTHASE |
2018 |
- Carlsson, Goran, U.
- Gustavsson, Bengt
- Odin, Elisabeth
- Wettergren, Yvonne
- Vedin, Anders
|
RU2775781C2 |
| METHOD FOR PRODUCING FOLIC ACID DERIVATIVE (6S)-ISOMERS |
1993 |
- Leonardo Ambrosini[It]
- Bruno Sala[It]
|
RU2109015C1 |
| STABLE CRYSTALLINE 6(S)- OR 6(R)-TETRAHYDROFOLIC ACID, METHODS OF THEIR PREPARING AND PHARMACEUTICAL COMPOSITION |
1995 |
- Gans Rudol'F Mjuller
- Martin Ul'Mann
- Rudol'F Mozer
- Tomas Amman
|
RU2165422C2 |
| STABLE CRYSTALLINE SALTS OF TETRAHYDROFOLIC ACID (VARIANTS), METHOD OF THEIR PREPARING AND PHARMACEUTICAL COMPOSITION |
1996 |
- Mjuller Khans Rudol'F
- Ul'Man Martin
- Mozer Rudol'F
- Amman Tomas
|
RU2187508C2 |
| 5-METHYLTETRAHYDROFOLIC ACID CRYSTALLINE ALKALINE-EARTH SALTS (VARIANTS), METHOD FOR THEIR PREPARING AND COMPOSITION FOR PHARMACEUTICAL AGENTS AND NUTRITION SUPPLEMENTS |
2000 |
- Mjuller Khans Rudol'F
- Mozer Rudol'F
- Ehgger Tomas
|
RU2265605C2 |
| METHODS FOR TREATMENT OF COLORECTAL AND METASTATIC COLORECTAL CANCER |
2019 |
- Ganlov, Karin
- Ostberg, Magnus
- Lindberg, Per, L.
- Sunden, Gunnel, E.
- Gustavsson, Bengt
|
RU2779535C2 |
| APPLICATION OF TETRAHYDROFOLATES OF NATURAL STEREOISOMER FORM AT OBTAINING PHARMACEUTICAL COMPOSITION INDICATED TO AFFECT HOMOCYSTEINE LEVEL, TO MAINTAIN THE PROCESS OF HOMOCYSTEINE REMETHYLATION, IN PARTICULAR |
1998 |
- Mjuller Khans Rudol'F
- Ul'Mann Martin
- Mozer Rudol'F
|
RU2226099C2 |
