DIAGNOSTIC TECHNIQUE FOR COGNITIVE DISORDERS ASSOCIATED WITH EXPOSURE TO PRODUCTION INDUCED MANAGANESE FROM EXTERNAL ENVIRONMENT IN CHILDREN FROM 5 TO 10 YEARS OLD Russian patent published in 2015 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: cognitive disorders are stated according to the clinical recognition and neuropsychological test results in a child. Child's blood is analysed to measure the manganese content, and if its content tends to increase more than the reference, the levels are stated: lipid hydroperoxide in blood serum, malondialdehyde MDA in blood plasma and 8-hydroxy-2-deoxyguanosine 8-OHdG in urine; glutathione peroxidase GlPO, Cu/Zn-superoxide dismutase Cu/Zn-SOD, antioxidant activity AOA of blood serum; glutamate and γ-aminobutyric acid in blood serum; hormones of the pituitary-adrenal axis: adrenocorticotropic hormone ACTH, cortisol and serotonine in blood serum, cyclic adenosine monophosphate cAMP and cyclic guanosine monophosphate cGMP. If the blood manganese content is more than 0.029 mcg/cm³ with at least 50% of the above clinical-laboratory values having the following characteristics: lipid hydroperoxide, MDA, 8-OHdG, glutamate, ACTH, cortisol, cGMP increased as compared to the age physiological norms; GlPO, Cu/Zn-SOD, AOA, γ-aminobutyric acid and cAMP reduced as compared to the age physiological norms, cognitive disorders associated with the exposure to manganese in the child.

EFFECT: using the invention provides high diagnostic accuracy.

2 cl, 1 ex