FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pyrroloquinolinyl pyrrolidine-2,5-diones of formula IVa, IVb, Va or Vb possessing the properties of cancer cell inhibitor properties, to a based pharmaceutical composition, and to a method of treating using them. In general formulas
,
R1, R2 and R3 mean hydrogen, F, Cl, Br, I, -(C1-C6) alkyl, CF3, -O-(C1-C6) alkyl, or -OCF3; R4 means hydrogen, - (C1-C6) alkyl or -CH2R7; R7 means -O-P(=O)(OH)2, -O-P(=O)(-OH)(-O-(C1-C6) alkyl), -O-P(=O)(-O-(C1-C6)alkyl)2, -O-P(=O)(-OH)(-O-(CH2)-phenyl), -O-P(=O)(-O-(CH2)-phenyl)2, groups of carboxylic acid, groups of aminocarboxylic acid or peptide; Q represents aryl, heteroaryl, -O-aryl, -S-aryl, -O-heteroaryl or -S-heteroaryl; X means -(CH2)- or -(NH)-; Y means -(CH2)- or a bond; wherein the above aryl, heteroaryl, -O-aryl, -S-aryl, -O-heteroaryl and -S-heteroaryl groups can be substituted by one or more substitutes, and m is equal to 1 or 2.
EFFECT: preparing the substances possessing the properties of cancer cell growth inhibitor.
26 cl, 2 tbl, 12 dwg, 88 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS AND METHODS OF TREATING CANCER | 2006 |
|
RU2409579C2 |
| PURIFIED PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS OF OBTAINING AND APPLICATION THEREOF | 2010 |
|
RU2556205C2 |
| USE OF HYDROGENATED DERIVATIVES OF PYRROLO[3,2,1-IJ]QUINOLIN-1-YLIDENE-2-THIOXOTHIAZOLIDIN-4-ONES AS INHIBITORS OF BLOOD COAGULATION FACTORS XA AND XIA | 2023 |
|
RU2819897C1 |
| SUBSTITUTED PYRROLS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2142460C1 |
| NEW ALKYLATING AGENTS | 2013 |
|
RU2632206C2 |
| SUBSTITUTED IMIDAZOPYRIDINYL-AMINO-PYRIDINE COMPOUNDS, USEFUL FOR TREATMENT OF CANCER | 2010 |
|
RU2619463C2 |
| USE OF SUBSTITUTED 2-(2-(4,4,6-TRIMETHYL-2-OXO-4N-PYRROLO[3,2,1-IJ]QUINOLINE-1(2H)-YLIDENE)HYDRAZINYL)THIAZOLE-4(5H)-ONES AS INHIBITORS OF BLOOD COAGULATION FACTORS XA AND XIA AND METHOD FOR THEIR PREPARATION | 2023 |
|
RU2819271C1 |
| TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | 2009 |
|
RU2530884C2 |
| 1,7-ANULAR DERIVATIVES OF 3-(PIPERAZINOALKYL)-INDOLE, METHOD OF THEIR SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND AN INTERMEDIATE COMPOUND FOR THEIR SYNTHESIS | 1992 |
|
RU2083580C1 |
| 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND VARIANTS OF THEIR USE | 2018 |
|
RU2795850C2 |
