FIELD: pharmacology; medicine.
SUBSTANCE: invention relates to inhibitors of blood coagulation factors Xa and XIa. Disclosed is the use of substituted 2-(2-(4,4,6-trimethyl-2-oxo-4H-pyrrolo[3,2,1-ij]quinoline-1(2H)-ylidene)hydrazinyl)thiazole-4(5H)-ones of general formula (I), where R1 is a substitute selected from hydrogen; phenyl without substitutes or substituted with halogen at position 4; R2 is a substituent selected from hydrogen; halogen; alkyl (C1-C2); alkoxy group (C1-C2), as inhibitors of blood coagulation factors Xa and XIa.
EFFECT: use of the invention enables to effectively inhibit coagulation factors Xa and XIa and can be used for treating and preventing thrombosis.
2 cl, 3 dwg, 10 ex
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