USE OF SUBSTITUTED 2-(2-(4,4,6-TRIMETHYL-2-OXO-4N-PYRROLO[3,2,1-IJ]QUINOLINE-1(2H)-YLIDENE)HYDRAZINYL)THIAZOLE-4(5H)-ONES AS INHIBITORS OF BLOOD COAGULATION FACTORS XA AND XIA AND METHOD FOR THEIR PREPARATION Russian patent published in 2024 - IPC A61K31/473 A61P7/02 

Abstract RU 2819271 C1

FIELD: pharmacology; medicine.

SUBSTANCE: invention relates to inhibitors of blood coagulation factors Xa and XIa. Disclosed is the use of substituted 2-(2-(4,4,6-trimethyl-2-oxo-4H-pyrrolo[3,2,1-ij]quinoline-1(2H)-ylidene)hydrazinyl)thiazole-4(5H)-ones of general formula (I), where R1 is a substitute selected from hydrogen; phenyl without substitutes or substituted with halogen at position 4; R2 is a substituent selected from hydrogen; halogen; alkyl (C1-C2); alkoxy group (C1-C2), as inhibitors of blood coagulation factors Xa and XIa.

EFFECT: use of the invention enables to effectively inhibit coagulation factors Xa and XIa and can be used for treating and preventing thrombosis.

2 cl, 3 dwg, 10 ex

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RU 2 819 271 C1

Authors

Shikhaliev Khidmet Safarovich

Novichikhina Nadezhda Pavlovna

Zorina Anna Vyacheslavovna

Podoplelova Nadezhda Aleksandrovna

Panteleev Mikhail Aleksandrovich

Dates

2024-05-16Published

2023-04-28Filed