FIELD: chemistry.
SUBSTANCE: invention relates to novel pyrroloquinolinyl-pyrrolidine-2,5-diones of formula IVa, IVb, Va or Vb or pharmaceutically acceptable salts thereof: 
where: R1, R2, R3 and R4 independently denote H; Q denotes a benzo-condensed 5-member heteroaryl with one N atom; X denotes -(CH2)-; Y denotes -(CH2)-, a bond; m equals 1 or 2.
EFFECT: compounds inhibit growth of cancerous cells, which enables their use in pharmaceutical compositions.
12 cl, 2 tbl, 12 dwg, 88 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS AND METHODS OF TREATING CANCER | 2006 |
|
RU2547148C2 |
| PURIFIED PYRROLOQUINOLINYL-PYRROLIDINE-2,5-DIONE COMPOSITIONS AND METHODS OF OBTAINING AND APPLICATION THEREOF | 2010 |
|
RU2556205C2 |
| USE OF HYDROGENATED DERIVATIVES OF PYRROLO[3,2,1-IJ]QUINOLIN-1-YLIDENE-2-THIOXOTHIAZOLIDIN-4-ONES AS INHIBITORS OF BLOOD COAGULATION FACTORS XA AND XIA | 2023 |
|
RU2819897C1 |
| SUBSTITUTED PYRROLS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2142460C1 |
| TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS | 2009 |
|
RU2530884C2 |
| USE OF SUBSTITUTED 2-(2-(4,4,6-TRIMETHYL-2-OXO-4N-PYRROLO[3,2,1-IJ]QUINOLINE-1(2H)-YLIDENE)HYDRAZINYL)THIAZOLE-4(5H)-ONES AS INHIBITORS OF BLOOD COAGULATION FACTORS XA AND XIA AND METHOD FOR THEIR PREPARATION | 2023 |
|
RU2819271C1 |
| NEW ALKYLATING AGENTS | 2013 |
|
RU2632206C2 |
| TRICYCLIC NITROGEN-CONTAINING COMPOUNDS AND TETRAHYDROQUINOLINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1991 |
|
RU2023712C1 |
| 6-SULFAMOYLQUINOLINE-4-CARBOXYLIC ACIDS, THEIR DERIVATIVES AND COMBINATORY LIBRARY | 2003 |
|
RU2229475C1 |
| SUBSTITUTED IMIDAZOPYRIDINYL-AMINO-PYRIDINE COMPOUNDS, USEFUL FOR TREATMENT OF CANCER | 2010 |
|
RU2619463C2 |
