2,3,5-TRISUBSTITUTED PYRROLS, BASED PHARMACEUTICAL COMPOSITION AND DRUG, METHOD FOR PREPARING COMPOUNDS (VERSIONS) Russian patent published in 2015 - IPC C07D207/34 C07D401/12 C07D403/12 C07D405/04 C07D405/12 C07D409/04 A61K31/4025 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, namely to compounds of formula (I), wherein R¹ and R² independently represent C₆-C₁₀ aryl optionally substituted by -OH, halogen, -OC₁-C₃ alkyl, -NO₂, -CF₃ or C₁-C₃ alkyl, or 5- or 6-merous heteroaryl containing one heteroatom specified in N, S and O; A and M independently represent a methylene group or a single bond; an adjacent aromatic cycle is attached directly to an amide group; the group Y=Z represents together and irregularly oxygen atom (-O-), cis-vinylidene group (-CH=CH-), iminogroup (-N=CH- or -CH=N-) or methylene group with sp²-hybridised carbon atom (=CH-); X irregularly represents methine group (=CH-), cis-vinylidene group (-CH=CH-) or carbon atom (=N-), and W represents hydroxyl group (-OH), C₁-C₆ alkyl optionally substituted by -SH, 5- or 6-merous heteroaryl containing 1 to 2 nitrogen heteroatoms, or C₆-C₁₀ aryl, optionally substituted by -SH, -NH_2, and their pharmaceutically acceptable salts.

EFFECT: described are the methods for preparing the compounds, using as a drug for treating cancer and the based pharmaceutical composition.

14 cl, 6 tbl, 49 ex