SARS-CoV-2 CORONAVIRUS MAIN PROTEASE INHIBITOR Russian patent published in 2025 - IPC C07D233/02 C07D403/12 C07D405/12 C07D407/12 C07D409/12 C07D411/12 C07D413/12 A61K31/404 A61K31/4166 A61P31/12 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), wherein R₁ is -CH(SO₃H)OH, -CN or -C(O)XR₃, where X is absent or denotes -O- or -CH₂O-, R₃ is hydrogen, C₁-C₆ alkyl, -PO₃H₂; m is 0 or 1; n is 0 or 1; A is -CH₂- or -C(O)-; ring B is a phenyl, indolyl, 5-membered heteroaryl containing 1 or 2 heteroatoms independently selected from N; each R₂ is independently selected from hydrogen, fluorine, phenyl, pyridyl, wherein R₂ is optionally substituted with one O-(C₁-C₆ alkyl). Invention also relates to the use of a compound of formula (I) to inhibit the main protease of coronavirus SARS-CoV-2.

EFFECT: creating the effective antiviral agent active as a high-specific inhibitor of SARS-CoV-2 coronavirus protease.

2 cl, 4 dwg, 1 tbl