NOVEL PYRROLE DERIVATIVES WITH HISTONE DEACETYLASE INHIBITING ACTIVITY Russian patent published in 2011 - IPC C07D207/34 C07D207/42 C07D409/04 C07D405/04 A61K31/40 A61P35/00 

Abstract RU 2416600 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel pyrrole derivatives of the formula I: , where R1 and R2 independently denote Ph; mono- or disubstituted in different positions of the ring Ph, where substitute denotes -OCH3; C5-heteroaryl with one heteroatom selected from O or S; R2 denotes H, NO2, NH2, C(O)NH2; R4 denotes H, a straight or branched C1-C6-alkyl; n equals the number of methylene groups and is between 1 and 8 inclusively; X denotes O, S, NH; Y NH, -CH2-; Z denotes O, S; W denotes -OH, hydroxylamine, hydrazine, alkylhydrazine.

EFFECT: compounds can inhibit histone deacetylase, which enables their use in cancer treatment.

10 cl, 9 dwg, 18 ex

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RU 2 416 600 C2

Authors

Kossio Mora Fernando Pedro

Ehstel'Er Badosa Manel

Zubia Olaskoaga Ajspea

Otajgi Ansa Dorleta

Dates

2011-04-20Published

2005-12-27Filed