NANOAGGREGATES OF WATER-SOLUBLE FULLERENE DERIVATIVES, METHOD FOR PREPARING THEM, COMPOSITIONS BASED ON NANOAGGREGATES OF WATER-SOLUBLE FULLERENE DERIVATIVES, USING NANOAGGREGATES OF WATER-SOLUBLE FULLERENE DERIVATIVES AND BASED COMPOSITIONS AS BIOLOGICALLY ACTIVE COMPOUNDS FOR REDUCING TOXICITY AND ENHANCING THERAPEUTIC ACTION OF DRUG PREPARATIONS, AND ALSO AS PREPARATIONS FOR TREATING ONCOLOGIC DISEASES Russian patent published in 2015 - IPC C07F9/40 C09C1/44 C01B31/00 C07C23/46 C07C61/28 C07D241/12 A61K31/25 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to nanoaggregates of water-soluble fullerene derivatives, which can be used for reducing toxicity and enhancing therapeutic action of drugs for oncologic diseases. There are presented nanoaggregates of water-soluble fullerene derivatives of general formula [C _2i (R) _m X _l ] _k, wherein k=3-1,000,000,000; wherein the values i, l, m, X and R are described by the following formulas: i=30, m=5, X=H, l=1, while R is a residue of thioic acid of formula -S(C_nH_2n)COOH, n=2 in the form of potassium salt; i=30, m=5, a X=H, l=1, R is a phosphonate residue of P(O)(OR⁴) (OR^4') (OR^4''), wherein R⁴, R^4', R^4'' are ethyl radical; i=30, m=5, X=Cl, l=1, while R is an aryl residue of formula -C₆H₄(C_nH_2n)COOH, wherein n=3, which can be presented in the form of potassium salt; i=35, m=8, l=0, while R is an aryl residue of formula -C₆H₄(C_nH_2n)COOH, wherein n=2, in the form of potassium salt.

EFFECT: there are presented new nanoaggregates, which can be effective in treating the oncologic diseases.

2 cl, 9 ex, 1 tbl, 11 dwg