USE OF WATER-SOLUBLE FULLERENE DERIVATIVES AS MEDICINAL PREPARATIONS OF NEUROPROTECTIVE AND ANTINEOPLASTIC ACTION Russian patent published in 2019 - IPC C01B32/152 A61P25/28 

Abstract RU 2704483 C2

FIELD: medicine.

SUBSTANCE: invention refers to medicine and aims at treating nervous system diseases. Disclosed is use of water-soluble derivatives of fullerene C60 in production of medicinal preparations of neuroprotective action. Fullerene derivatives of formula I are used, containing 5 hydrophilic groups on one hemisphere of fullerene frame, while other half remains non-functionalised. Compounds have hydrophobic and hydrophilic fragments in their structure, which provides ease of their penetration through cell membranes.

EFFECT: invention enables controlling mitochondrial activity and provides cytoprotective (antioxidant) action on different cell types.

1 cl, 6 dwg, 2 ex

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Authors

Fu-Yu Se

Zhilenkov Aleksandr Viktorovich

Voronov Ilya Igorevich

Khakina Ekaterina Aleksandrovna

Mishchenko Denis Valerevich

Troshin Pavel Anatolevich

Shan-Khuej Su

Dates

2019-10-29Published

2017-06-20Filed