APPLICATION OF AMINE DERIVATIVES OF FULLERENES C60 AND C70 AND BASED ON THEM COMPOSITIONS AS ANTIMICROBIAL PREPARATIONS Russian patent published in 2014 - IPC A61K31/435 A61K31/495 A61K33/44 A61P31/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the chemical-pharmaceutical industry and deals with application of fullerene derivatives of the general formula 1

,

where in the general formula 1 fragment C_2n stands for: fullerene carbon cage C₆₀ (n=30), C₇₀ (n=35); where in the general formula 1 "x" can take values from 4 to 12, and "y" from 0 to 16, where in the general formula 1 fragment A stands for a monovalent atom of fluorine or hydrogen; -oxygen atom (-O-), bound to the fullerene cage in a composition of an oxirane fragment; where in the general formula 1 NR¹R² is described by the following definitions: - amine residue, where R¹ and R² are hydrogen atoms or substituted with protonated (NH₃ ⁺) or unprotonated (NH₂) aminogroups or branched alkyl radicals (C_mH_2m+1; m=1-20); - residue of piperazine of the general formula Ic-1 , where R, R'₁, R'₂ R'₃ and R'₄ are hydrogen atoms or linear or branched alkyl (C_mH_2m+1 m=1-20) radicals, as antimicrobial preparations, as well as an antimicrobial composition, including fullerene derivatives.

EFFECT: invention can be used in biomedical research and in production of novel medications, intended for treatment and prevention of infectious diseases, as well as for creation of disinfection agents, intended for decontamination and sterilisation of media and surfaces contaminated with microorganisms.

2 cl, 4 ex, 2 tbl, 4 dwg