FIELD: medicine.
SUBSTANCE: invention refers to immunology. What is disclosed is using a peptide with an amino acid sequence GLAGGSAQSQRAPDRVL for selecting CεmX-specific antibodies and antigen-binding fragments of these antibodies. What is presented is the CεmX-specific antibody, as well as a method providing selecting the antibodies specifically binding the peptide according to the invention, and a method of treating IgE-mediated diseases involving administering the antibody into an individual according to the invention.
EFFECT: it has been disclosed that the monoclonal antibodies specifically binding the CεmX segment GLAGGSAQSQRAPDRVL can effectively bind to mIgE in human B-cells and are applicable for targeting to these B cells for treating IgE-mediated diseases.
14 cl, 5 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PEPTIDE IMMUNOGENS AND COMPOSITIONS CONTAINING SAID IMMUNOGENS TARGETING MEMBRANE-BOUND IGE FOR TREATING IGE-MEDIATED ALLERGIC DISEASES | 2017 |
|
RU2769983C2 |
| METHOD FOR DETECTION OF IgE-PRODUCING B-LYMPHOCYTES | 1988 |
|
RU2047177C1 |
| METHOD OF PREPARING ANTIBODIES SPECIFICALLY BINDING WITH JG E | 1988 |
|
RU2082428C1 |
| NOVEL ANTI-IL13 ANTIBODIES AND USE THEREOF | 2004 |
|
RU2487887C2 |
| ISOLATED ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT SPECIFIC FOR HUMAN IMMUNOGLOBULIN E (VERSIONS), NUCLEIC ACID MOLECULE CODING IT, HOST CELL, METHOD FOR PREPARING ANTIBODY OR ITS ANTIGEN-BINDONG FRAGMENT, PHARMACEUTICAL COMPOSITION, USE THEREOF FOR TREATING IgE-ASSOCIATED DISEASES | 2008 |
|
RU2466140C2 |
| FcγRIIB RECEPTOR ANTIBODIES AND APPLICATION THEREOF | 2005 |
|
RU2404991C2 |
| ANTIBODIES | 2005 |
|
RU2482131C2 |
| MONOCLONAL ANTIBODIES AGAINST IL-21 OF HUMAN BEING | 2008 |
|
RU2504552C2 |
| APOPTOTIC ANTIBODIES AGAINST IgE | 2008 |
|
RU2500686C2 |
| BISPECIFIC BINDING AGENTS WITH INTERSPECIFIC SPECIFICITY | 2008 |
|
RU2535992C2 |
