FIELD: medicine, medicinal industry. SUBSTANCE: invention describes antigenic epitopes IgE (designed as ige. b1 present on IgE-producing β-lymphocytes). One class of ige. b1-epitopes is bound with or near binding FCER-site on IgE. Other class ige. b1-epitopes associates with extracellular domain segment of E-chains that fixes IgE on B-cell membrane (E.ml/ec). Invention describes method of preparing antibodies that were bound with ige. b1-epitopes and used for treatment of allergic states induced by IgE. For animal immunization the following peptide is used that is conjugated with mollusk hemocyanin: Glu-Leu-Asp-Val-Cys-Val-Glu-Glu-Ala-Glu-Glu-Ala-Pro. EFFECT: improved method of antibodies preparing. 3 dwg, 7 tbl
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