FIELD: medicine.
SUBSTANCE: there is described a recovered anti-FcγRIIB/anti-FcεRIα bispecific antibody unable of cross-linking with human FcγRIIA. There are offered methods of immune response inhibition in a mammal, immune response related histamine release inhibition in a mammal, and treatment involving the introduction of described bispecific antibody. There are presented a composition for FcεRI activity inhibition in the recovered cells of mammals, a composition for FcγRIIB activation in the recovered cells of mammals expressing FcγRIIB by combined aggregation of FcγRIIB and FcεRIα and a composition for FcεRI receptor expression inhibition in the recovered cells containing the described antibody as an active material.
EFFECT: invention allows making bispecific anti-FcγRIIB, anti-FcεRIα antibodies.
49 cl, 65 dwg, 2 tbl, 5 ex
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