ENCAPSULATED LYPOSOMAL ANTIVIRAL AGENT BASED ON HUMAN INTERFERON ALPHA-2b FOR VAGINAL APPLICATION Russian patent published in 2015 - IPC A61K9/48 A61K9/127 A61K38/21 A61K47/48 A61P31/12 

Abstract RU 2552851 C1

FIELD: medicine.

SUBSTANCE: invention represents an encapsulated liposomal antiviral agent based on human interferon alpha-2b for vaginal application, characterised by the fact that each capsule is made in the form of a hollow coating, which encloses a powder excipient and liposomes distributed in the excipient, and sodium alginate, a water-soluble polymer gel former; the excipient consists of lactose, sodium chloride, 12-aqueous disodium hydrogen phosphate and sodium dihydrogen phosphate, whereas each of the liposomes represents a hollow coating containing lecithin, cholesterol and alpha-tocopherol, and a nucleus inside the coating and containing recombinant human interferon alpha-2; the ingredients of the agents are taken in a certain ratio, mg.

EFFECT: maintaining the storage activity of recombinant human interferon alpha-2 and prolonged action in vaginal application.

2 cl, 3 dwg, 6 tbl, 6 ex

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RU 2 552 851 C1

Authors

Khomichev Vadim Valentinovich

Naumova Nina Vasil'Evna

Smolina Margarita Petrovna

Vojtenko Aleksandr Vasil'Evich

Targonskaja Oksana Viktorovna

Targonskij Sergej Nikolaevich

Dates

2015-06-10Published

2014-03-28Filed