SUBSTITUTED 3-PHENYLPROPIONIC ACIDS AND USING THEM Russian patent published in 2015 - IPC C07C233/55 C07C255/60 C07D305/06 C07C231/02 C07C253/30 A61K31/167 A61K31/277 A61K31/337 A61P9/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to 3-phenylpropionic acid derivatives of formula

wherein R^1A represents hydrogen, methyl, ethyl, cyclopropyl or cyclobutyl, R^1B is hydrogen or methyl, R^2A represents hydrogen, methyl, trifluoromethyl, ethyl or n-propyl, R^2B is hydrogen or methyl or R^1A and R^2A are combined together, and in a combination to carbon atoms to which they are attached, form a cyclopropyl ring of formula

wherein R^1B and R^2B have the values as specified above, or R^2A and R^2B are combined together, and in a combination to a carbon atom, to which they are attached, form a cyclic group of formula or

wherein n means a number 1 or 2, R³ is hydrogen, fluorine or methyl, R⁴ represents hydrogen, fluorine, chlorine or a cyanogroup, R^5A represents methyl, R^5B is trifluoromethyl or R^5A and R^5B are combined together, and in a combination to a carbon atom, to which they are attached, form a difluorosubstituted cycloalkyl ring of formula or

R⁶ represents chlorine, alkyl with 1-4 carbon atoms, alkenyl with 2-4 carbon atoms, cyclopropyl or cyclobutyl; alkyl with 1-4 carbon atoms and alkenyl with 2-4 carbon atoms can contain up to three fluorine atoms, cyclopropyl and cyclobutyl up to three fluorine atoms as substitutes, and R⁷ represents hydrogen, fluorine, chlorine, methyl or a methoxy group. The invention also refers to a therapeutic agent containing the above compounds and to a method for producing the compounds of formula (I).

EFFECT: compounds of formula (I) activate the form of soluble haem-free guanylate cyclase and are applicable in the method of treating and/or preventing cardiac failure, angina, hypertension, pulmonary hypertension, ischemia, vascular diseases, disturbed microcirculation, thromboembolic diseases and arterial sclerosis.

6 cl, 4 tbl, 113 ex