SUBSTITUTED TETRAHYDROPYRANSPIROPYRROLIDINONE AND TETRAHYDROPYRANSPIROPIPERIDINONE, BASED ON THEM PHARMACEUTICAL COMPOSITION AND APPLICATION FOR THERAPEUTIC PURPOSES Russian patent published in 2014 - IPC C07D491/107 A61K31/407 A61K31/438 A61P25/00 

Abstract RU 2519778 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention describes a group of substituted N-phenylbipyrrolidincarboxamides of formula (I), where m equals 1 or 2; n equals to 1 or 2; p equals to 1 or 2; R1 is hydrogen, (C1-C4)-alkyl, CF3, (C1-C4)-alkoxy-(C1-C4)-alkyl; and R2 is hydrogen, halogen, (C1-C4)-alkyl or CF3; or their salt, or enantiomer, or diastereomer. In particular, compounds in accordance with the invention are modulators of H3 receptors and, therefore, are suitable for application as pharmaceutical preparations, in particular, in treatment and (or) prevention of different diseases, modulated by H3 receptors, including diseases associated with the central nervous system.

EFFECT: obtained are novel compounds, possessing useful biological properties.

15 cl, 1 tbl, 44 ex

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RU 2 519 778 C2

Authors

Gao Chzhunli

Khartung Rajan

Stefani Dehvid

Dates

2014-06-20Published

2009-12-04Filed