METHOD OF PREDICTING RESISTANCE TO INFECTIOUS DISEASES IN CHILD OF FIRST YEAR OF LIFE Russian patent published in 2015 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: immunological indices in umbilical blood and venous blood on 4-5 day of life are determined. Resistance coefficient (Cres) is calculated by formula Cres=4.95258-0.0143955×(PI)+0.0962295×(PN)-0.00903362×(IgG)-0.257936×(IgA)-0.324514×(IgM)+0.430186×(CD45+CD3+)-1.66224×(CD45+CD4+CD3+)+l.49266×(CD45+CD8+CD3+)+0.815254×(CD4+CD8+)+0.522212×(HLA-DR+)-23.1991×(CD3+HLA-DR+)+0.974106×(CD3+CD25+)+0.832493×(CD3+CD4+CD25+)-3.52478×(CD16+CD56+CD3-)+7.67325×(CD16+CD56-CD3-)+11.082×(CD16+CD56+CD3+)+0.305366×(CD19+)+0.0691703×(CD5+)+0.0610707×(CD3+), where PI is phagocytic index, PN is phagocytic number, IgG, M, A are immunoglobulins of respective classes, CD are lymphocyte differentiation markers. If Cres value constitutes 1.78 and higher, when calculated by values of indices, obtained from umbilical blood, and is lower than 5.72, when counted by values of indices, obtained from venous blood on 4-5 day of life, on the first day of life high degree of resistance to infectious diseases is expected during the first year of life.

EFFECT: application of claimed method makes it possible to predict frequency of development of infectious diseases in child of the first year of life and take preventive measures to reduce risk of high morbidity.

2 tbl