METHYLHYDROFUMARATE PRODRUGS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR USING Russian patent published in 2015 - IPC C07C235/06 C07C235/08 C07C235/10 C07C235/12 C07C259/06 C07C271/64 C07C275/50 C07C69/75 C07C69/78 C07C69/96 C07C69/60 C07D207/16 C07D263/20 C07D285/135 C07D295/185 A61K31/16 A61K31/225 A61K31/401 A61K31/421 A61K31/433 A61K31/495 A61K31/5377 A61P17/06 A61P9/10 A61P19/02 A61P11/00 

Abstract RU 2554347 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound of formula , which is a methylhydrofumarate (MHF) prodrug. In formula (I), radicals and symbols have the values specified in the patent claim. The invention also refers to a pharmaceutical composition containing the declared methylhydrofumarate drugs, to using the declared methylhydrofumarate drugs and the pharmaceutical composition containing them, for treating diseases, such as psoriasis, asthma, multiple sclerosis, inflammatory intestinal disease and arthritis, and to a method of treating the above diseases.

EFFECT: higher oral bioavailability and plasma MHF, dimethylfumarate and/or other metabolites.

47 cl, 1 tbl, 54 ex

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RU 2 554 347 C2

Authors

Gangakkhedkar Archana

Dai Sjuehdong

Zerang Noa

Virsik Piter A.

Dates

2015-06-27Published

2009-08-19Filed