METHOD FOR PREDICTION OF PROGRESSION OF VENTRICULAR ARRHYTHMIA IN PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS Russian patent published in 2015 - IPC G01N33/573 

FIELD: medicine.

SUBSTANCE: invention describes a method for the prediction of the progression of ventricular arrhythmia in the patients with postinfarction cardiosclerosis (PICS) by examining the patients; in the patients suffered the acute myocardial infarction less than one year before the examination, and having a low ventricular arrhythmia frequency, the standard medical therapy including a β-adrenoreceptor blocking agent is combined with measuring enzyme activity in peripheral blood lymphocytes: NADP-dependent malate dehydrogenase (NADPMDG), NADP-dependent glutamate dehydrogenase (NADPGDG), glutathione reductase (GR) and NADPN-dependent glutamate dehydrogenase (NADPN-GDG) that is followed by measuring an intracellular NADPN-metabolic rate (INMR) representing the total NADPMDG and NADPGDG activity related to the total GR and NADPN-GDG activity, i.e. INMR=(NADPMDG+NADPGDG)/(GR+NADPN-GDG); if the INMR is more than 0.0028, the progression of ventricular arrhythmia is predicted for two years following the acute myocardial infarction; the INMR of 0.0028 or less shows maintaining the low ventricular arrhythmia frequency for two years following the acute myocardial infarction.

EFFECT: method enables the well-timed detection of the progression of ventricular arrhythmia in the PICS patients suffered the acute myocardial infarction two years before and can be recommended for application in clinical practice.

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