FIELD: medicine. SUBSTANCE: preparation has conjugate of an enzyme hyaluronidase with high-molecular synthetic carrier polyoxydonium (molecular mass is 40 000-100 000 Da). Preparation has molecular links (n) in the amount 300-700, alkylated links in the amount (0.2-0.4) x n, oxidizing links in the amount (0.4-0.8) x n at ratio enzyme : carrier = 1:(1-5). Specific activity of enzyme hyaluronidase is 1 000-2 500 IU/mg that can be prepared from cattle testicles. EFFECT: enhanced effectiveness of preparation. 2 tbl
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Authors
Dates
1998-06-10—Published
1997-02-28—Filed