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2 699 053

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IPC

G01N33/58(2006-01-01)

C12Q1/6827(2018-01-01)

C12Q1/6876(2018-01-01)

(21) (22)

Application

2018134814, 2018-10-03

(24)

Start date

2018-10-03

(22)

Actual filing date

2018-10-03

(45)

Published

2019-09-03

(72)

Inventor

Kadochnikova Vladislava ViktorovnaKofiadi Ilya AndreevichNikiforova Alena IgorevnaZobkova Gaukhar Yurevna

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennostyu Firma Dnk-Tekhnologiya"

METHOD FOR HUMAN GENOTYPE DETERMINATION BY POLYMORPHISM IN MATRIX METALLOPROTEINASE 3 (MMR3) -11715A/6A GENE Russian patent published in 2019 - IPC G01N33/58 C12Q1/6827 C12Q1/6876

Abstract RU 2699053 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, biology and biotechnology and aims at determining human genotype by polymorphism in matrix metalloproteinase 3 (MMP3) -1171>5A/6A gene. A pair of primers common for all alleles, fluorescent-labeled allele-specific oligonucleotide probes and a universal oligonucleotide labeled with a fluorescence quencher are used. Referring the sample to a homozygote or a heterozygote by the allele is determined by a DNA melting profile shape that is a maximum of the first fluorescence curve derivative.

EFFECT: invention enables to determine the genotype in one test tube, which reduces the cost of the study.

1 cl, 1 dwg, 2 tbl

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RU 2 699 053 C1

Authors

Kadochnikova Vladislava Viktorovna

Kofiadi Ilya Andreevich

Nikiforova Alena Igorevna

Zobkova Gaukhar Yurevna

Dates

2019-09-03—Published

2018-10-03—Filed