FIELD: medicine, pharmaceutics.
SUBSTANCE: inventions relate to the field of biotechnology and deal with a method of preventing or treatment of a disease in a subject, caused by a pathogenic organism, by the introduction of a vaccine composition, the vaccine composition and its application. The characterised vaccine composition contains bacteria, attenuated by mutation in a gene, coding the ABC-peptide transporter protein OppD, which can persist in the subject. The claimed inventions can be applied in immunology to obtain and apply vaccines.
EFFECT: said mutation makes the coded ABC-peptide transporter protein non-functional.
19 cl, 10 dwg, 21 tbl, 5 ex
