ATTENUATED BACTERIA BORDETELLA PERTUSSIS, WHOOPING COUGH AGENT VACCINE Russian patent published in 2012 - IPC A61K39/10 C12N1/20 C07K14/235 

FIELD: medicine.

SUBSTANCE: invention discloses attenuated bacteria B pertussis, containing the mutant genes ptx and dnt showing no dermonecrotic toxin activity, however having kept an ability to link with an eukaryotic cell receptor. The bacteria under the invention produce a genetically changed immunologically non-toxic toxoidal form of pertussis toxin. The invention concerns the bacterial strain B.pertussis containing said mutant genes which is deposited in the Collections of Strains of Gamaleya Research Institute of Epidemiology and Microbiology, No. 171/331 B.p KS-4. The strain is applicable as a vaccine. The whooping cough agent vaccine contains the living attenuated bacteria or the inactivated attenuated bacteria B.pertussis.

EFFECT: experimental intranasal immunisation in vivo with the vaccine containing the living or inactivated attenuated bacteria Bpertussis under the invention provides the effective and prolonged protection against infection by the virulent strain of the whooping cough agent.

4 cl, 4 dwg, 6 tbl, 5 ex