Show metadata Hide metadata

(19)

(11)

2 559 937

(13)

(51)

IPC

G09B23/28(2006-01-01)

A61K35/14(2015-01-01)

A61P9/10(2006-01-01)

(21) (22)

Application

2014133331/14, 2014-08-12

(24)

Start date

2014-08-12

(22)

Actual filing date

2014-08-12

(45)

Published

2015-08-20

(72)

Inventor

Orlova Anzhelika Jur'EvnaArtjushkova Elena BorisovnaSukovatykh Boris SemenovichGordov Maksim Jur'EvichAbramova Svetlana Al'Bertovna

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija Rossijskoj Federatsii

METHOD FOR PHARMACOLOGICAL STIMULATION OF NEOANGIOGENESIS IN TREATING ACUTE EXPERIMENTAL LIMB ISCHEMIA Russian patent published in 2015 - IPC G09B23/28 A61K35/14 A61P9/10

Abstract RU 2559937 C1

FIELD: medicine.

SUBSTANCE: acute limb ischemia is simulated in Wistar male rats by excising a segment of great vessels containing a femoral artery, a popliteal artery and initial segments of shin arteries. The operation is performed under chloral hydrate anaesthesia in a dose of 250-300 mg/kg. Through 5 days immediately following the surgery, Actovegin is introduced intraperitoneally in a dose of 50 mcg/kg daily once a day.

EFFECT: method provides stimulating neoangiogenesis and activation of developing collateral blood flow in the ischemic limb and thereby improvement of the arterial blood inflow from the proximal portions of the limb into distal ones.

1 ex, 1 tbl

Similar patents RU2559937C1

Title	Year	Author	Number
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING SILDENAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY	2016	Lavrinenko Kristina Ivanovna Belous Aleksandr Sergeevich Mal Galina Sergeevna Artyushkova Elena Borisovna Polyakova Olga Vitalevna Orlova Anzhelika Yurevna Trubnikova Elena Vladimirovna	RU2618621C1
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING VARDENAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY	2016	Lavrinenko Kristina Ivanovna Belous Aleksandr Sergeevich Mal Galina Sergeevna Artyushkova Elena Borisovna Polyakova Olga Vitalevna Orlova Anzhelika Yurevna Trubnikova Elena Vladimirovna	RU2618622C1
METHOD FOR SKELETAL MUSCLE EXPERIMENTAL ISCHEMIA PHARMACOLOGICAL CORRECTION USING TADALAFIL AND PENTOXIFYLLINE IN COMBINED THERAPY	2016	Lavrinenko Kristina Ivanovna Belous Aleksandr Sergeevich Mal Galina Sergeevna Artyushkova Elena Borisovna Polyakova Olga Vitalevna Orlova Anzhelika Yurevna Trubnikova Elena Vladimirovna	RU2618620C1
METHOD OF TREATING CHRONIC LIMB ISCHEMIA EXPERIMENTALLY	2014	Orlova Anzhelika Jur'Evna Sukovatykh Boris Semenovich Artjushkova Elena Borisovna Gordov Maksim Jur'Evich	RU2556606C1
METHOD FOR PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL CRITICAL SKELETAL MUSCLE ISCHEMIA WITH SIMVASTATIN	2020	Fejziev Elvin Ejnulla Ogly Belous Aleksandr Sergeevich Sukovatykh Boris Semenovich Trubnikova Elena Vladimirovna	RU2726076C1
METHOD FOR PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL CRITICAL SKELETAL MUSCLE ISCHEMIA WITH A COMBINATION OF SIMVASTATIN AND MONONUCLEAR FRACTION OF AUTOLOGOUS BONE MARROW	2020	Fejziev Elvin Ejnulla Ogly Belous Aleksandr Sergeevich Sukovatykh Boris Semenovich Trubnikova Elena Vladimirovna	RU2735838C1
METHOD FOR STIMULATING NEOANGIOGENESIS IN ISCHEMIC SKELETAL MUSCLE	2014	Kolesnik Inga Mikhajlovna Pokrovskij Mikhail Vladimirovich Lazarenko Viktor Anatol'Evich	RU2547692C1
METHOD OF PHARMACOLOGICAL CORRECTION OF ISCHEMIA OF SKELETAL MUSCLE WITH RESVERATROL	2012	Pokrovskij Mikhail Vladimirovich Lazarenko Viktor Anatol'Evich Kolesnik Inga Mikhajlovna Trofimov Konstantin Sergeevich Pokrovskaja Tat'Jana Grigor'Evna Dolzhikov Aleksandr Anatol'Evich Khodov Sergej Vladimirovich Gudyrev Oleg Sergeevich Kochkarov Vladimir Iskhakovich Stupakova Elena Gennad'Evna	RU2518965C1
METHOD OF PHARMACOLOGICAL CORRECTION OF SCELETAL MUSCLE ISCHEMIA WITH SILNEDAFIL INCLUDING IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY	2012	Pokrovskij Mikhail Vladimirovich Kolesnik Inga Mikhajlovna Khodov Sergej Vladimirovich Pokrovskaja Tat'Jana Grigor'Evna Dolzhikov Aleksandr Anatol'Evich Efremenkova Dar'Ja Afonas'Evna Gudyrev Oleg Sergeevich Molchanova Ol'Ga Viktorovna Kochkarov Vladimir Iskhakovich Zhernakova Nina Ivanovna Dolzhikova Irina Nikolaevna Danilenko Ljudmila Mikhajlovna Bratchikov Oleg Ivanovich Filimonov Vjacheslav Aleksandrovich Arustamova Anna Aleksandrovna Korokin Mikhail Viktorovich Gureev Vladimir Vladimirovich Korokina Lilija Viktorovna Alekhin Sergej Aleksandrovich Denisjuk Tat'Jana Alekseevna	RU2497203C2
METHOD FOR PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL CRITICAL SKELETAL MUSCLE ISCHEMIA WITH A COMBINATION OF SIMVASTATIN AND UDENAFIL	2020	Fejziev Elvin Ejnulla Ogly Belous Aleksandr Sergeevich Sukovatykh Boris Semenovich Trubnikova Elena Vladimirovna	RU2727891C1

RU 2 559 937 C1

Authors

Orlova Anzhelika Jur'Evna

Artjushkova Elena Borisovna

Sukovatykh Boris Semenovich

Gordov Maksim Jur'Evich

Abramova Svetlana Al'Bertovna

Dates

2015-08-20—Published

2014-08-12—Filed