FIELD: medicine.
SUBSTANCE: shin muscle ischemia is simulated in laboratory animals on the second experimental day by surgical removal of a portion of great vessels, including femoral, popliteal, anterior and posterior tibial arteries. The ischemia is corrected by the intragastric administration of dihydroquercetin in a daily dose of 5.5 mg/kg every 46 hours of the first 7 experimental days.
EFFECT: effective treatment of the skeletal muscle ischemia by stimulating neoangiogenesis that is proved by laser Doppler flowmetry and morphological analysis.
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Authors
Dates
2015-04-10—Published
2014-02-13—Filed