NOVEL METHOD FOR ISOMERISATION OF CONDENSED BICYCLIC STRUCTURES AND OBTAINING VITAMIN D ANALOGUES CONTAINING SAID STRUCTURES Russian patent published in 2015 - IPC C07C49/403 C07C401/00 A61K31/59 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a cis-condensed bicyclic derivative of formula (II) from a corresponding trans-condensed bicyclic derivative of formula (I), which includes a step of reacting said trans-condensed bicyclic derivative with a hydride base of formula M-H, where M is an atom of group IA. In general formula (I) and (II) R¹ is H or a C₁-C₆ alkyl group; R² is H or D; where D is a deuterium atom; R³ is C₁-C₂₀ alkyl, optionally containing one or more double or triple bonds, and/or optionally containing one or more heteroatoms selected from O, N, S, Si; m is an integer selected from 0, 1, 2, 3; n is an integer selected from 0, 1 or 2; when they are present, each Rⁱ and R^j, which are identical or different, respectively denote 1 to m or 1 to n groups, identical or different, independently selected from a halogen atom, C₁-C₆ alkyl, C₂-C₆ alkenyl, OR, NRR', CN, NO₂, perhalogeno (C₁-C₆)alkyl, COR, COOR, CONRR', alkylaryl, alkenylaryl, where R, R', identical or different, are selected from H, alkyl and aryl.

EFFECT: providing a method of producing a cis-condensed bicyclic derivative of formula (II).

12 cl, 6 ex