SPIRO AMINO COMPOUNDS APPLICABLE FOR TREATING SLEEP DISORDERS AND DRUG ADDICTION Russian patent published in 2015 - IPC C07D401/12 C07D401/14 C07D417/06 C07D417/14 A61K31/438 A61K31/4427 A61K31/497 A61K31/506 A61P25/30 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention related to a spiro amino compound of formula

,

wherein m represents 1 or 2 or 3, n represents 1 or 2, R is specified in a 6-merous aromatic ring and a 5-merous heteroaromatic ring containing 1 to 2 heteroatoms specified in S and N; this ring is substituted by one or two substitutes specified in a group consisting of (C₁-C₃)alkyl, halogen atom, (C₃-C₅)cycloalkyloxygroup, phenyl optionally substituted by one or more halogen atoms, 5- or 6-merous heterocycle containing at least one nitrogen atom specified in 1,2,3-triazole, pyrimidine, pyridine, and pyrazine; P represents a substitute Q, wherein Q is specified in a group consisting of phenyl, pyridyl, pyrimidyl; Q is optionally substituted by one or more substitutes specified in a group consisting of (C₁-C₃)alkyl, halogen, trifluoromethyl, methylcarboxygroup. The invention also refers to a spiro amino compound of formula (VI), wherein m represents 1 or 3, n represents 1 or 2, R represents phenyl substituted by the substitute cyclopropyl (C₁-C₃)alkoxy, P represents a substitute Q, wherein Q is specified in a group consisting of phenyl, pyridyl, pyrimidinyl; Q is optionally substituted by one or more substitutes specified in a group consisting of (C₁-C₃)alkyl, halogen, trifluoromethyl and methylcarboxygroup. The compounds of formula IV are applicable to produce a drug preparation for treating the pathologies, which require an orexin receptor 1 antagonist to be applied.

EFFECT: spiro amino compounds possessing the orexin receptor agonist activity.

19 cl, 99 ex