5-(7H-PYRROLO[2,3-d]PYRIMIDINE-4-YL)-5-AZASPIRO[2.5]OCTANE-8-CARBOXYLIC ACID DERIVATIVES AS NEW JAK-KINASE INHIBITORS Russian patent published in 2021 - IPC C07D487/04 A61K31/519 A61P17/00 A61P37/00 

FIELD: medicine.

SUBSTANCE: present invention relates to a compound corresponding to the general formula I or to its pharmaceutically acceptable salt, hydrate or solvate, which are inhibitors of Janus kinase, to a pharmaceutical composition containing these compounds, and to a method for the prevention, treatment or relief of immune system diseases

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In the formula I, X is NH or O; R₁ and R₂, each independently, are selected from a group consisting of hydrogen, deuterium, hydroxyl, (C₁-C₃)alkyl and hydroxy(C₁-C₃)alkyl; n is an integer selected from 1-3; Y is a chemical bond, -C(O)O-*, -C(O)OR₃-* or -C(O)NHR₃-*, where * is a point of attachment to W, and where R₃ is (C₁-C₄)alkylene; W is selected from a group consisting of phenyl, pyridyl, (C₃-C₇)cycloalkyl and 4-6-element heterocycloalkyl containing one heteroatom selected from O and S, where the specified phenyl, pyridyl, (C₃-C₇)cycloalkyl and 4-6-element heterocycloalkyl containing one heteroatom selected from O and S is optionally substituted with one or more substituents independently selected from hydroxyl, cyano, halogen, oxo, (C₁-C₄)alkyl, hydroxyl(C₁-C₄)alkyl, cyano(C₁-C₄)alkyl, (C₁-C₄)alkoxy and -SO₂NH₂.

EFFECT: obtaining compounds for the treatment of immune system diseases.

18 cl, 2 tbl, 164 ex