COMPOUNDS FOR TREATING CANCER Russian patent published in 2017 - IPC C07D233/66 C07D277/24 C07D277/42 C07D403/04 C07D417/12 A61K31/415 A61K31/426 A61K31/4178 A61K31/427 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of structural formula (XI), where X is NH; Q is NH or S; and A is a substituted or unsubstituted furanyl, indolyl, phenyl, biphenyl, triphenyl, diphenylmethane, thiophenyl, adamantanyl or fluorenyl; wherein said ring A is optionally substituted with 1-5 substituents, which are independently O-alkyl, O-haloalkyl, F, Cl, Br, I, haloalkyl, CF₃, CN, -CH₂CN, NH₂, hydroxyl, -(CH₂)_iNHCH₃, -(CH₂)_iNH₂, -(CH₂)_iN(CH₃)₂, -OC(O)CF₃, C₁-C₅ straight or branched alkyl, haloalkyl, alkylamino, aminoalkyl, -OCH₂Ph, -NHCO-alkyl, COOH, -C(O)Ph, C(O)O-alkyl, C(O)H, -C(O)NH₂ or NO₂; and i is an integer from 0 to 5. Compound of formula (XI) can be in form of an isomer, pharmaceutically acceptable salt thereof, tautomer or hydrate. Invention also relates to a pharmaceutical composition for treating cancerous diseases, containing said compound and pharmaceutically acceptable carrier. Compound of formula (XI) is intended for treatment, suppression, reducing degree, reducing risk, inhibiting cancer, treating drug-resistant tumour or tumours or destruction of cancer cells. Said cancer is selected from a group consisting of prostate cancer, breast cancer, ovarian cancer, skin cancer, melanoma, metastatic melanoma, lung cancer, colon cancer, leukaemia, kidney cancer, CNS cancer and combinations thereof. Said tumour is selected from a group Consisting melanoma tumour, tumour metastatic melanoma, tumor of prostate cancer and ovarian tumour.

EFFECT: technical result is compounds with anticancer activity.

12 cl, 38 dwg, 33 tbl, 30 ex