FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, more specifically to producing labelled antibodies, and can be used for diagnostic purposes. The antibodies are engineered with replacing one or more amino acids of a basic antibody by non-cross-coupling high-reactive cysteine amino acids. The engineered cysteine antibodies (Ab) are conjugated with one or more labels with a zirconium complex through a linker (L) for producing zirconium-labelled engineered cysteine antibodies conjugates having formula I: Ab-(L-Z)p, wherein p represents 1-4.
EFFECT: invention enables providing more effective diagnosis ensured by using the radioactive zirconium-labelled engineered cysteine antibodies for imaging purposes.
15 cl, 29 dwg, 12 tbl, 23 ex
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