FIELD: biotechnology.
SUBSTANCE: proposed strain is reproduced in a monolayer culture of pig kidney cells (PK), passaged cultures PSGK-30, BHK-21 and IBRS-2, for 18-24 hours of incubation the virus yield in these cell cultures reaches the values of 6.63-7.5 lg TCD 50/cm3. At high multiplicity of infection (1-10 TCD/cell) it causes TCD after 5 hours, while maintaining the initial characteristics in passaging in cell cultures for 10 passages.
EFFECT: strain may be used to control the antigenic and immunogenic activity of FMD vaccines and for production of biological products for diagnostics and specific prevention of FMD of type O.
6 cl, 1 dwg, 8 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| STRAIN O N 2311/ZABAIKALSKY/2016 FOOT AND MOUTH DISEASE VIRUS TYPE APHTAE EPIZOOTICAE TYPE O FOR MANUFACTURING OF BIOLOGICS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF FOOT AND MOUTH DISEASE OF TYPE O | 2017 |
|
RU2658608C1 |
| STRAIN O NO_2212/PRYMORSKY/2014 OF APHTAE EPIZOOTICAE FOOT AND MOUTH DISEASE VIRUS OF O TYPE FOR THE CONTROL OF THE ANTIGENIC AND IMMUNOGENIC ACTIVITY OF FOOT-MOUTH DISEASE VACCINES AND FOR THE MANUFACTURE OF BIOLOGIC DRUGS FOR DIAGNOSTICS AND SPECIFIC PREVENTION OF FOOT AND MOUTH DISEASE OF O TYPE | 2016 |
|
RU2650768C1 |
| STRAIN O №2108/ZABAIKALSKY/2010 OF FOOT-AND-MOUTH DISEASE VIRUS Aphtae epizooticae OF TYPE O FOR MANUFACTURING BIOLOGICAL PREPARATIONS FOR DIAGNOSTICS OF FOOT-AND-MOUTH DISEASE VIRUS OF TYPE O | 2014 |
|
RU2575801C1 |
| INACTIVATED EMULSION VACCINE FOR O-TYPE APHTHOUS FEVER | 2017 |
|
RU2682876C1 |
| INACTIVATED EMULSION VACCINE AGAINST FOOT-AND-MOUTH DISEASE TYPE O | 2017 |
|
RU2665849C1 |
| STRAIN O N 2356/PAKISTAN/2018 FOOT-AND-MOUTH DISEASE VIRUS APHTAE EPIZOOTICAE GENOTYPE O/ME-SA/PANASIA2 FOR THE MANUFACTURE OF BIOPREPARATIONS FOR THE DIAGNOSIS OF FOOT-AND-MOUTH DISEASE | 2023 |
|
RU2801950C1 |
| STRAIN N2344/MONGOLIA/2017 VIRUS OF FOOT-AND-MOUTH DISEASE OF APHTAE EPIZOOTICAE O TYPE FOR MAKING BIOPREPARATIONS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF FOOT-AND-MOUTH DISEASE OF O TYPE | 2019 |
|
RU2708326C1 |
| INACTIVATED SORBED VACCINE AGAINST FMD OF TYPE A | 2014 |
|
RU2563345C1 |
| STRAIN OF FMD VIRUS Aphtae epizooticae OF TYPE A FOR CONTROLLING ANTIGENIC AND IMMUNOGENIC ACTIVITY AND FOR PRODUCTION OF BIOLOGICAL PREPARATIONS FOR DIAGNOSTICS AND SPECIFIC PROPHYLAXIS OF FMD OF TYPE A | 2014 |
|
RU2553219C1 |
| VACCINE FOR EARLY PROTECTION AGAINST FOOT-AND-MOUTH DISEASE OF TYPE O INACTIVATED EMULSION | 2019 |
|
RU2699671C1 |
