FIELD: biotechnology.
SUBSTANCE: invention relates to a new strain of foot-and-mouth disease, Aphtae epizooticae virus of O genotype, Picornaviridae family, Aphthovirus genus deposited in the All-Russian State Collection of Exotic Types of Foot-and-Mouth Disease Virus and Other Animal Pathogens (GKSM) FGBI "ARRIAH" under registration number No.415 - dep/22-49 — GKShM FGBI "ARRIAH". The strain is reproduced in continuous cultures of kidney cells of the Siberian mountain ibex PSGK-30, in continuous culture of pig kidney cells IBRS-2, retaining the original characteristics when passaged in cell culture for 5 passages. In a continuous cell culture BHK-21/SUSP/ARRIAH, when incubated for 12–14 hours, the titer of infectious activity of strain O No. 2356/Pakistan/2018 of foot-and-mouth disease virus is 7.40±0.14 lg TCD50/cm3, the concentration of total viral protein is 3.15±0.12 μg/cm3, 146S component is 2.15±0.08 µg/cm3 (68.4%). The strain O No. 2356/Pakistan/2018 of foot and mouth disease virus, when studied on susceptible animals, showed high infectious activity, which in cattle was 6.25 lg ID50/0.1 cm3, in pigs — 7.75 lg ID50/0.1 cm3.
EFFECT: strain can be used for the manufacture of biopreparations for the diagnosis and specific prevention of FMD O/ME-SA/PanAsia2ANT-10 genotype and to control the antigenic activity of FMD vaccines.
1 cl, 1 dwg, 4 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2810131C1 |
| O N 2620/ORENBURG/2021 STRAIN OF FOOT AND MOUTH DISEASE VIRUS APHTAE EPIZOOTICAE GENOTYPE O/ME-SA/IND-2001E FOR PRODUCTION OF BIOLOGICAL PRODUCTS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF FOOT AND MOUTH DISEASE | 2023 |
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|
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| CULTURAL INACTIVATED EMULSION VACCINE AGAINST FOOT AND MOUTH DISEASE FROM O NO. 2620/ORENBURGSKY/2021 STRAIN OF O/ME-SA/IND-2001E GENOTYPE | 2023 |
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| STRAIN A 2205/G IV OF THE TYPE A FOOT-AND-MOUTH DISEASE VIRUS APHTAE EPIZOOTICAE FOR PRODUCING BIOLOGICAL AGENTS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF TYPE A FOOT-AND-MOUTH DISEASE | 2021 |
|
RU2773659C1 |
| A/EGYPT/EURO-SA/2022 STRAIN OF APHTAE EPIZOOTICAE FOOT-AND-MOUTH DISEASE VIRUS FOR MANUFACTURE OF BIOPREPARATIONS FOR DIAGNOSIS AND SPECIFIC PREVENTION OF FOOT-AND-MOUTH DISEASE GENOTYPE A/EURO-SA | 2023 |
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| A/IRAN/2018 STRAIN OF FOOT-AND-MOUTH DISEASE VIRUS APHTAE EPIZOOTICAE OF TYPE A FOR THE MANUFACTURE OF BIOLOGICAL PRODUCTS FOR THE DIAGNOSTICS AND SPECIFIC PREVENTION OF FOOT-AND-MOUTH DISEASE OF TYPE A | 2022 |
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RU2799602C1 |
