METHOD OF TREATING ISCHEMIC HEPATIC INJURIES Russian patent published in 2015 - IPC G09B23/28 A61K31/7076 A61K31/7008 A61K33/14 A61P39/06 A61P31/04 

FIELD: medicine.

SUBSTANCE: hepatectomy using an intraoperative extracorporeal temporal portacaval shunt is performed in an experimental animal. On the day of the surgical intervention, the slow intravenous bolus administration of Heptral, the solution for injections, follows 1.5 hours prior to the surgical intervention in a dose of 2 mg/kg, 2 hours after the first administration - in a dose of 6 mg/kg and 8 hours after the first administration - in a dose of 4 mg/kg. What is also required is the slow intravenous bolus administration of Clarithromycin in NaCl solution 0.5 in a dose of 3 mg/kg three times a day at 7⁰⁰, 15⁰⁰ and 23⁰⁰. The postoperative period involves administering Heptral two times a day - at 9⁰⁰ in a dose of 7 mg/kg, at 16⁰⁰ in a dose of 5 mg/kg; Clarithromycin - three times a day at 7⁰⁰, 15⁰⁰ and 23⁰⁰ in a dose of 3 mg/kg. The total length of administering Heptral and Clarithromycin is 10 days.

EFFECT: method provides treating, correcting and preventing a surgical infection, ischemic and reperfusion hepatic injuries, lengthening safe periods of liver exsanguinations and avoiding major haemorrhages potentially accompanying the hepatic surgical intervention.

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