METHOD FOR PREVENTING AND TREATING HEPATIC CONSEQUENCES OF ISCHEMIA Russian patent published in 2012 - IPC G09B23/28 A61K31/4045 A61K31/44 A61P1/16 

FIELD: medicine.

SUBSTANCE: liver is resected in an animal experimentally. A pharmacological protection is presented by Mexicor and Serotonine Adipinate. On the operation day, 5% Mexicor is used in the form of intravenous slow stream introductions twice - 35 minutes before the operation in a dose of 5 mg/kg of weight and 11 hours after the first introduction in a dose of 7 mg/kg of weight. Serotonine Adipinate dissolved in 5 ml of isotonic solution NaCl is used in the form of intravenous slow stream introductions three times - 1 hour before the operation in a dose of 0.15 mg/kg of weight, 2 hours after the first introduction in a dose of 0.2 mg/kg of weight, 10 hours after the first introduction in a dose of 0.1 mg/kg of weight. During the postoperative period, Mexicor and Serotonine Adipinate are introduced for 8 days. Mexicor is introduced three times a day at 9 o'clock in a dose of 2.5 mg/kg of weight, at 15 o'clock in a dose of 1.5 mg/kg of weight, at 21 o'clock in a dose of 6 mg/kg of weight. Serotonine Adipinate is introduced twice a day - at 8 o'clock in a dose of 0.15 mg/kg of weight, at 17 o'clock in a dose of 0.1 mg/kg of weight.

EFFECT: method provides prolonging a period of safe hepatic exsanguination, ensures treating and preventing ischemic and reperfusion injuries of hepatic tissues and microcirculatory bloodstream, promotes preventing major bleedings accompanying hepatic operations.

3 ex, 3 tbl, 3 dwg