FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical industry, namely to method of obtaining asiaticoside. Method of obtaining asiaticoside of at least 99% purity includes treatment of milled Centella asiatica material with petroleum ether; extraction of treated milled material with aliphatic alcohol, alone or in combination with water; distillation and dissolution of extract or filtrate in methyl isobutyl ketone with obtaining solution; passing solution through layer of resin and elution with alcohol solvent with obtaining eluate; concentration of eluate in vacuum with obtaining asiaticoside powder; dissolution of powder in alcohol (versions). Method of treatment and prevention of disease, selected from the group, including of inflammatory bowel disease, haemorrhoids, anal fissure, fistula, gastric disease, gastric carcinoma and elimination of Helicobacter pylori infection or their any combination, includes introduction of asiaticoside to patient, possibly together with pharmaceutically acceptable excipient(s).
EFFECT: method makes it possible to obtain asiaticoside of at least 99% purity.
16 cl, 10 tbl, 14 ex
Title |
Year |
Author |
Number |
METHOD OF TREATING HYPERCORTISOLEMIA, HEADACHES, NEUROPATHIC PAIN AND RELATED DISORDERS |
2011 |
- Baskaran Sunil
- Vishvaraman Mokhan
|
RU2561588C2 |
COMBINED EXTRACTS FROM ANDROGRAPHIS PANICULATA |
2005 |
- Jan' Sjaotsjan
- Van Tao
- Ma Chzhimin
- Chzhan Vehjkhan'
- Duan Tszifehn'
- Tsaj Juj
|
RU2383353C2 |
APPLICATION OF ANDROGRAPHOLIDE IN PREPARATION OF PHARMACEUTICAL DRUG FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE, ANDROGRAPHOLIDE ENTERIC TARGETING MICROPELLET, AND METHOD FOR PREPARATION THEREOF |
2014 |
- Sun, Henry
- Ma, Xiaohui
- Guo, Zhixin
- Lin, Sen
- Wang, Genbei
- Yan, Lulu
- Zhang, Lihua
- Zhou, Shuiping
- Zhang, Shunnan
|
RU2681930C2 |
PREPARATION CONTAINING DIAMINOTRIFLUOROMETHYL PYRIDINE DERIVATIVE FOR TREATING AND PREVENTING ALIMENTARY DISEASES |
2001 |
- Etsuja Suiti
- Kimura Khirokhiko
- Bamba Tadao
|
RU2266114C2 |
NEW LACTOBACTERIA CHARACTERIZED BY VARIOUS FUNCTIONS, AND ITS APPLICATION |
2016 |
- Kim, Dong Hyun
- Han, Myung Joo
|
RU2734031C2 |
METHOD OF OBTAINING PLECTRANTHUS AMBOINICUS EXTRACTS, EXTRACT, OBTAINED BY THIS METHOD, AND BASED ON IT PHARMACEUTICAL COMPOSITION, UNPURIFIED PLECTRANTHUS AMBOINICYS EXTRACT AND BASED ON IT PHARMACEUTICAL COMPOSITION, BANDAGE MATERIAL BASED ON SAID COMPOSITIONS AND SAID COMPOSITIONS AS PREPARATION IN MANUFACTURING MEDICATION FOR TREATING SKIN DISORDERS |
2008 |
- Syu Ma-Li
- U Zhej-Juj
- U Juj-Juan'
- Khsyao Chin'-Vehn'
- Chun Juj-Shan'
|
RU2440819C2 |
SUSPENSION FOR ORAL ADMINISTRATION WITH ANTI-ULCER AND CHEMOPROTECTIVE EFFECTS IN COLON CANCER AND METHOD OF ITS USE |
2020 |
- Gonzalez Canavaciolo Victor Luis
- Vicente Murillo Roxana
- Rodriguez Zamora Reynerio
- Benitez Guerra Niurka
- Rodriguez Leyes Eduardo Antonio
- Molina Cuevas Vivian
- Mendoza Castato Sarahi
- Oyarzabal Yera Ambar
|
RU2806636C1 |
METHOD OF PREVENTING GASTROINTESTINAL DISEASES IN ANIMALS OR PEOPLE, METHOD OF TREATING GASTROINTESTINAL DISEASES IN ANIMALS OR PEOPLE AND MEDICATION FOR TREATMENT OR PREVENTION OF GASTROINTESTINAL DISEASES IN ANIMALS OR PEOPLE |
2006 |
- Sas Benedikt
- Van Khemel' Jokhan
- Vandenkerkkhove Jan
- Pejs Ehrik
- Tan' Khaj Meng
- Se Chea-Jun
- Ramchand Chanijilparampu
- Vargiz Dzherri
|
RU2412241C2 |
COP1 FOR TREATMENT OF INFLAMMATORY DISEASES OF INTESTINE |
2004 |
- Akharoni Rina
- Arnon Rut
- Kajkhan Basak
|
RU2339397C2 |
NEW STRAIN OF BIFIDOBACTERIUM, CHARACTERIZED BY DIFFERENT FUNCTIONS, AND APPLICATION THEREOF |
2020 |
- Kim, Dong Hyun
- Han, Myung Joo
|
RU2766715C2 |