METHOD OF OBTAINING HIGHLY PURIFIED ASIATICOSIDE COMPOSITION FROM Centella asiatica AND METHOD OF APPLICATION THEREOF Russian patent published in 2015 - IPC A61K31/704 A61P1/00 

Abstract RU 2565410 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, namely to method of obtaining asiaticoside. Method of obtaining asiaticoside of at least 99% purity includes treatment of milled Centella asiatica material with petroleum ether; extraction of treated milled material with aliphatic alcohol, alone or in combination with water; distillation and dissolution of extract or filtrate in methyl isobutyl ketone with obtaining solution; passing solution through layer of resin and elution with alcohol solvent with obtaining eluate; concentration of eluate in vacuum with obtaining asiaticoside powder; dissolution of powder in alcohol (versions). Method of treatment and prevention of disease, selected from the group, including of inflammatory bowel disease, haemorrhoids, anal fissure, fistula, gastric disease, gastric carcinoma and elimination of Helicobacter pylori infection or their any combination, includes introduction of asiaticoside to patient, possibly together with pharmaceutically acceptable excipient(s).

EFFECT: method makes it possible to obtain asiaticoside of at least 99% purity.

16 cl, 10 tbl, 14 ex

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RU 2 565 410 C2

Authors

Sunil Bkhaskaran

Mokhan Vishvaraman

Dates

2015-10-20Published

2010-08-31Filed