FIELD: chemistry.
SUBSTANCE: crystalline microparticles consisting of formoterol or its pharmaceutically acceptable salts and myristic acid in amount of 1.0 to 2.0% by weight are described. Myristic acid forms continuous film on surface of microparticles. Crystalline microparticles are used in production of pharmaceutical aerosol compositions in the form of suspension in liquefied propellant gas or in the form of powder compositions. Method of producing microparticles and metered-dose inhaler under pressure filled with aerosol composition has been also described. Crystalline microparticles are used for prevention and/or treatment of respiratory disease, such as asthma or chronic obstructive pulmonary disease.
EFFECT: crystalline microparticles of the invention are characterized by improved stability and composition of such particles with improved aerosol characteristics.
9 cl, 1 dwg, 4 tbl, 6 ex
