HETEROARYL COMPOUNDS AS IRAK TYPE II INHIBITORS AND THEIR USE Russian patent published in 2023 - IPC C07D471/04 C07D487/04 C07D495/04 A61K31/437 A61K31/519 A61P19/02 A61P29/00 A61P35/00 A61P37/00 

FIELD: organic chemistry.

SUBSTANCE: group of inventions includes a compound of formula I, its pharmaceutically acceptable salt, a pharmaceutical composition containing it, a method of inhibition and a method of treatment. In formula I, A' represents either C=O, CH₂, CHOH or NH; L represents a divalent group selected from the following: C_6-10 aryl, 3–8 membered saturated or partially unsaturated carbocyclic ring; each of which is optionally substituted with one or two halogens; X represents either CR or N; Y represents NR or S; Z represents either CR or N; R¹ represents C_6-10 aryl, which is optionally substituted with one or two substituents selected from halogen, C_1-6 alkyl or -CN; R² represents -R, C_1-6 haloalkyl; each R independently represents hydrogen, C_1-6 alkyl, a saturated 3–7 membered heterocyclic ring containing 1 heteroatom representing oxygen; each of which is optionally substituted with one substituent selected from C_1-6 alkyl, -OH or -CN.

EFFECT: compound of formula (I) with inhibitory activity against IRAK.

20 cl, 31 ex