ARYLFLUOROPHOSPHATE INHIBITORS OF INTESTINAL APICAL MEMBRANE SODIUM/PHOSPHATE CO-TRANSPORT Russian patent published in 2015 - IPC C07F9/14 C07F9/20 C07F9/26 A61K31/683 A61P9/12 

FIELD: chemistry.

SUBSTANCE: present invention relates to inhibitors of intestinal apical sodium/phosphate co-transport for treating conditions associated with hyperphosphatemia of formula I:

,

pharmaceutically acceptable salts thereof and pharmaceutical compositions based thereon, where R is C_2-4alkyl; W is O or S; Z is a single bond or -C(O)-; X¹ and X² are -OH; m equals 1 or 2; and n equals 1 or 2.

EFFECT: novel efficient inhibitors of intestinal apical sodium/phosphate co-transport are disclosed.

32 cl, 6 ex