TETRAHYDROPYRANYL AMINO-PYRROLOPYRIMIDINONE AND METHODS OF ITS USE Russian patent published in 2021 - IPC A61K31/519 A61P35/00 C07D487/04 

Abstract RU 2747991 C1

FIELD: medicine.

SUBSTANCE: invention relates to a method for treating cancer in a person in need thereof. The method includes detecting a mutant BTK in a sample from a person, wherein the mutant BTK includes a C481S mutation; administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof when a mutant BTK is detected.

EFFECT: new method of treatment based on a compound of formula (I) or a pharmaceutically acceptable salt thereof, which can be used in medicine.

15 cl, 1 tbl, 5 ex

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RU 2 747 991 C1

Authors

Lapierre, Jean-Marc

Eathiraj, Sudharshan

Namdev, Nivedita

Schwartz, Brian

Ota, Yusuke

Momose, Takayuki

Tsunemi, Tomoyuki

Inagaki, Hiroaki

Nakayama, Kiyoshi

Dates

2021-05-18Published

2020-02-18Filed