FIELD: chemistry; pharmaceutics.
SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, which are mTORC1 inhibitors. In formula (I), R1 is selected from the group consisting of hydrogen and hydroxyl-C1-6alkyl, and R2 is 
, where n is 1, 2 or 3. Invention also relates to specific compounds of formula (I). 
(I)
EFFECT: disclosed are derivatives of rapamycin containing isothiazolidine-1,1-dioxide and 1,4-butanesultone, and ways of using them.
7 cl, 1 dwg, 2 tbl, 4 ex
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