FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to method of obtaining derivatives of 5-[(2-hydroxyacyl)amino]2,4,6-triiodo derivative of general formula 
(5) or its pharmaceutically acceptable salt, where R independently in each case represents group, selected from -COOR' and -CON(R')2; R' independently in each case represents hydrogen or linear or branched (C1-C4) alkyl group, optionally substituted with one or several hydroxyl groups as such or in their protected form; and X represents hydrogen or linear or branched (C1-C4) alkyl group; by Smiles rearrangement of compound of general formula 
(4) or its salt, where R, R' and X are such as determined above, and said rearrangement is achieved by contact of compound (4) with solid phase of ion-exchanger in presence of water solvent.
EFFECT: obtaining derivatives of 5-[(2-hydroxyacyl)amino]2,4,6-triiodo-1,3-benzenecarboxamide with high output and high optic purity degree.
10 cl, 4 ex
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