PHOSPHODIESTERASE 10 MODULATORS Russian patent published in 2015 - IPC C07D231/14 C07D233/90 C07D401/14 C07D403/12 C07D413/12 C07D413/14 C07D417/12 C07D417/14 C07D471/04 A61K31/4155 A61K31/4178 A61K31/4192 A61K31/4196 A61K31/422 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to formula compound, in which X and X₁ independently represent CR⁴ or N; Y and Y₁ independently represent C or N; Z and Z₁ independently represent CR⁶, NR⁷, N, O or S; R¹ and R² are independently selected from C₁-C₇-alkyl, C₃-C₈-cycloalkyl, or R¹ and R², together with nitrogen atom, they are bound to, form spirobicyclic saturated ring system, including from 5 to 12 ring atoms, including heteroatoms, selected from N, O, or 4-, 5- or 6-membered heterocycloalkyl, containing 1 or 2 heteroatoms, selected from N, O, S, which can contain from 1 to 3 substituents, independently selected from halogen; R³ represents C₁-C₇-alkyl; R⁴ represents hydrogen, C₁-C₇-alkyl, C₁-C₇-halogenalkyl or halogen; R⁵ represents phenyl or heteroaryl, with both groups probably containing C₁-C₇-alkyl, halogen, C₁-C₇-alkoxygroup as substituent; R⁶ represents hydrogen, C₁-C₇-alkyl or R⁵ and R⁶, together with Y₁ and Z atom, which they are bound to, form phenyl ring, possibly substituted with C₁-C₇-alkyl, halogen; R⁷ represents C₁-C₇-alkyl, C₃-C₈-cycloalkyl, C₁-C₇-halogenalkyl, C₁-C₇-alkoxyalkyl, phenyl, heteroaryl or C₁-C₇-alkyl, possibly substituted with phenyl or C₃-C₈-cycloalkyl, or R⁵ and R⁷, together with Y₁ and Z atom, which they are bound to, form heteroaryl, possibly substituted with C₁-C₇-alkyl, C₁-C₇-halogenalkyl; W is selected from ethylene, possibly substituted with C₁-C₇-alkyl, and to its physiologically acceptable salts.

EFFECT: claimed compounds inhibit PDE 10A phosphodiesterase and can be applied as medications.

18 cl, 65 ex, 1 tbl