PIPERIDINYLPYRAZOLOPYRIMIDINONES AND USE THEREOF Russian patent published in 2020 - IPC C07D487/04 A61K31/519 A61K31/5377 A61K31/541 A61K45/06 A61P7/04 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel substituted piperidinylpyrazolopyrimidinones, having structural formula (I-A), in which radicals and symbols have the definitions given in the claim, methods for preparing them, based medicinal agents, use thereof in a method of treating and/or preventing diseases.

EFFECT: compounds can be used for treating and/or preventing acute and recurrent haemorrhage in patients with underlying hereditary or acquired haemostatic disorders or without them, where haemorrhage is associated with a disease or medical intervention selected from a group including severe menstrual bleeding, postpartum haemorrhage, haemorrhoid shock, haemorrhagic cystitis, gastrointestinal bleeding, trauma, surgical intervention, transplantation, stroke, liver disease, hereditary angioedema, nosebleed and synovitis and cartilage damage following haemarthrosis.

18 cl, 4 tbl, 472 ex