NOVEL PYRAZINE DERIVATIVES Russian patent published in 2017 - IPC C07D241/18 C07D241/24 C07D401/12 C07D403/04 C07D405/12 C07D405/14 C07D409/14 C07D413/12 C07D413/14 C07D417/12 C07D417/14 A61K31/4965 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) modulate activity of cannabinoid receptor 2 (CB2).

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In formula (I) R¹ is a halophenyl or C3-C6-cycloalkyl-C1-C6-alkoxy; R² is a C3-C6-cycloalkyl, azetidinyl or difluoroazetidinyl; one of R³ and R⁴ is hydrogen, and other is -(CR⁵R⁶)-R⁷ or -A-R⁷; or R² is a C3-C6-cycloalkyl, and R³ and R⁴ together with a nitrogen atom, to which they are bonded, form piperidinylamine; R⁵ and⁶ are independently selected from hydrogen, C1-C6-alkyl, halogen-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, phenyl, phenyl-C1-C6-alkyl and halophenyl; or R⁵ and⁶ together with carbon atom, to which they are bonded, form C3-C6-cycloalkyl or oxetanyl; R⁷ is cyano, carboxy, 5-methyl-[1,2,4]oxadiazol-3-yl, 5-amino-[1,2,4]oxadiazol-3-yl, thiazolyl, C1-C6-alkylthiazolyl, pyridinyl, C1-C6-alkylaminocarbonyl, hydroxy-C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, aminocarbonyl, C1-C6-alkoxycarbonyl, di-C1-C6-alkylaminocarbonyl, phenyl-C1-C6-alkyl, pyridinyl-C1-C6-alkyl, halogen-C1-C6-alkylaminocarbonyl, 5-phenyl-2-methyl-oxazol-4-yl-alkyl, aminocarbonyl-C1-C6-alkyl or halogen; and A is cyclohexyl or thiophenyl, under condition specified in patent claim. Invention also relates to individual compounds, pharmaceutical composition, use of compounds and to a method of modulating CB2 receptor activity.

EFFECT: technical result is obtaining novel compounds of formula (I) modulating activity of cannabinoid receptor 2 (CB2).

19 cl, 111 ex