FIELD: chemistry.
SUBSTANCE: invention relates to crystalline γ-modification of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide monohydrate (thiotropium bromide monohydrate), method of its obtaining and thereof-based pharmaceutical composition, which can be applied as anticholinergic preparation with specificity to muscarinic receptors for treatment of asthma or chronic obstructive pulmonary disease.
EFFECT: claimed γ-modification possesses improved solubility.
5 cl, 2 tbl 5 dwg, 4 ex
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