FIELD: medicine.
SUBSTANCE: invention refers to a new crystalline ε-modification of N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluor-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-carboxamide malate, to a method for producing it and using the same for preparing a pharmaceutical composition as an antitumour agent, tyrosine kinase inhibitor for treating oncological diseases.
EFFECT: more effective use of the compositions.
4 cl, 6 dwg, 3 tbl, 5 ex
| Title |
Year |
Author |
Number |
| METHOD FOR PRODUCING AN AMORPHOUS FORM OF N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOLE-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROL-3-CARBOXAMIDE MALATE, PRODUCT AND APPLICATION THEREOF FOR TREATING ONCOLOGICAL AND IMMUNOLOGICAL DISEASES |
2021 |
- Torchinov Georgij Yurevich
|
RU2774382C1 |
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2004 |
- Blasko Andrej
- Tszin' Tsinvu
- Lu Tsjun'
- Morejdzhis Majkl Ehntoni
- Song Dong
- Vondervell Brenda S'Ju
|
RU2319702C2 |
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2015 |
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- Malin Aleksandr Aleksandrovich
|
RU2568638C1 |
| DERIVATIVES OF INDOLIN-2-SHE AS INHIBITORS OF PROTEINKINAS |
2013 |
- Chern Tszi-Van
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- Van Khsyao-Chun
- Chen Grejs Shiakhu
|
RU2627706C2 |
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2008 |
- Tan Pehn Chzho
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- Chzhao Futsjan
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| METHOD FOR PREPARING INDOLINONE DERIVATIVES |
2003 |
- Dzin Kvingvu
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- Mehj Pol D.
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RU2299209C2 |
| PRODRUGS OF 3-ACYL-2-HYDROXYINDOLE-1-CARBOXAMIDES, PHARMACEUTICAL COMPOSITION |
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- Akhmetova Vnira Rakhimovna
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