FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to the field of immunology. Claimed are a separated antibody-antagonist against FGFR3 and its functional fragment, as well as a polynucleotide, vector of expression, host cell and method of obtaining the antibodies against FGFR3 or its functional fragment. In addition, analysed are pharmaceutical compositions and the application of the antibody or its functional fragment by the invention for the treatment or prevention of cancer and a skeleton disease, as well as for the inhibition of cell proliferation and/or reduction of the quantity of cancer cells.
EFFECT: claimed invention can be applied in the therapy of diseases, associated with the activation and/or overexpression of FGFR3.
20 cl, 24 dwg, 5 tbl
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