FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to immunology. There are presented versions of antibodies specifically bound with amino acid residues of murine 1446-1725 Notch1 or human 1446-1735 Notch1. What is disclosed is a coding polynucleotide, an expression vector based on the polynucleotide, a host cell for antibody expression. What is described is a method for producing the antibody with the use of the vector, as well as using the antibodies as a therapeutic agent or in a method of treating the disorders associated with higher signal transmission or higher Notch1 expression.
EFFECT: use of the invention provides the antibodies which reduces the Notch1 signal transmission that can find application in medicine for treating the disorders associated with higher Notch1 expression.
42 cl, 17 dwg, 5 tbl, 10 ex
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