METHODS OF TREATING CANCER USING PD-1 AXIS BINDING AND VEGF ANTAGONISTS Russian patent published in 2019 - IPC A61K39/395 C07K16/28 C07K16/22 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, specifically, oncology, and can be used to treat or slow the development of cancer in a subject. To this end, an effective amount of an anti-PD-L1 antibody, a VEGF antagonist, oxaliplatin, leucovorin and 5-FU are administered to a subject, wherein the anti-PD-L1 antibody comprises a heavy chain variable region and a light chain variable region, wherein (a) the heavy chain variable region comprises HVR-H1, HVR-H2 and HVR-H3, wherein (i) HVR-H1 comprises the amino acid sequence SEQ ID NO: 15; (ii) HVR-H2 includes the amino acid sequence SEQ ID NO: 16; (iii) HVR-H3 comprises the amino acid sequence SEQ ID NO: 3; (b) the light chain variable region comprises HVR-L1, HVR-L2 and HVR-L3, where (iv) HVR-L1 includes the amino acid sequence SEQ ID NO: 17; (v) HVR-L2 comprises the amino acid sequence SEQ ID NO: 18; (vi) HVR-L3 includes the amino acid sequence SEQ ID NO: 19. Kit is also provided for treating or slowing down the development of cancer in a subject.

EFFECT: group of inventions increases tumour immunogenicity for the treatment of cancer.

23 cl, 4 dwg, 2 ex